A Systematic Review of Global Research on Research Questions

Document Type : Review Paper

Authors

Department of Knowledge and Information Science, Faculty of Social and Educational Sciences, Razi University, Kermanshah, Iran.

10.22059/jlib.2026.408255.1807

Abstract

Objective: The aim of this study is to provide a systematic overview of global research on research questions and to identify the main thematic axes, methodological approaches, and existing gaps in this field. Despite the fundamental role of research questions in shaping scientific inquiry, evidence suggests that this topic has received limited attention in domestic scholarship and, even at the international level, lacks a comprehensive and coherent classification.
Method: This study employs a systematic review methodology. In the initial stage, more than 200 articles were identified. After applying inclusion criteria related to relevance, methodological quality, and scholarly significance, 67 key studies were selected for final analysis. The selected studies were first classified into three main categories and subsequently organized into more specific subcategories.
Results: The findings indicate that research on research questions is primarily concentrated in three areas: criteria for evaluating and formulating research questions, disciplinary domains, and scholarly book-based resources. Within the evaluation criteria domain, the FINER framework remains the most dominant model, while more developed frameworks such as FINERMAPS and RIN.AFE are used far less frequently. In terms of the formulation and structuring of research questions, no clear theoretical consensus exists, with approaches ranging from linear models to dynamic and iterative processes. Regarding disciplinary domains, medical sciences account for the largest share of studies, and the development of structured frameworks such as PICO(T) reflects the specific demands of clinical research. Other fields, including artificial intelligence and the humanities, have adopted diverse but fragmented approaches.
Conclusion: The results suggest that the field of research questions is expanding and evolving globally; however, it remains characterized by conceptual fragmentation and a lack of comprehensive critical frameworks. While the formulation of research questions constitutes the primary focus of existing studies, evaluation criteria have undergone relatively limited theoretical development. By providing a coherent mapping of the current state of the literature, this study emphasizes the need for greater attention within the social sciences and humanities to the theoretical dimensions of research questions. It further demonstrates that improving the quality of research questions plays a crucial role in enhancing research methods education and advancing the production of scientific knowledge.

Keywords


Agee, J. (2009). Developing qualitative research questions: A reflective process. International Journal of Qualitative Studies in Education, 22(4), 431-447. https://doi.org/10.1080/09518390902736512
Alvesson, M., & Sandberg, J. (2013). Constructing research questions: Doing interesting research. Sage. http://digital.casalini.it/9781529675320
Andrews, R. (2003). Research questions. https://digital.casalini.it/9781441106766
Aslam, S., & Emmanuel, P. (2010). Formulating a researchable question: A critical step for facilitating good clinical research. Indian Journal of Sexually Transmitted Diseases and AIDS, 31(1), 47. https://doi.org/10.4103/0253-7184.69003
Bandholm, T., Christensen, R., Thorborg, K., Treweek, S., & Henriksen, M. (2017). Preparing for what the reporting checklists will not tell you: the PREPARE Trial guide for planning clinical research to avoid research waste. British Journal of Sports Medicine, 51(20), 1494-1501. https://doi.org/10.1136/bjsports-2017-097527
Bansard, E. (2024). Building an Interdisciplinary Research Question. Psycho-Oncologie, 18(2), 79-85.
Barroga, E., & Matanguihan, G. J. (2022). A practical guide to writing quantitative and qualitative research questions and hypotheses in scholarly articles. Journal of Korean medical science, 37(16). https://doi.org/10.3346/jkms.2022.37.e121
Beck, S., Brasseur, T.-M., Poetz, M., & Sauermann, H. (2022). Crowdsourcing research questions in science. Research Policy, 51(4), 104491. https://doi.org/10.1016/j.respol.2022.104491
Booth, A., Noyes, J., Flemming, K., Moore, G., Tunçalp, Ö., & Shakibazadeh, E. (2019). Formulating questions to explore complex interventions within qualitative evidence synthesis. BMJ Global Health, 4(Suppl 1), e001107.
Cambridge University Press. (n.d.). Criterion. In Cambridge Dictionary. Retrieved November 25, 2025, from https://dictionary.cambridge.org/dictionary/english/criterion
da Costa Santos, C. M., de Mattos Pimenta, C. A., & Nobre, M. R. (2007). The PICO strategy for the research question construction and evidence search. Revista Latino-Americana de Enfermagem15(3), 508–511. https://doi.org/10.1590/s0104-11692007000300023
Connelly, L. M. (2015). Research questions and hypotheses. Medsurg Nursing, 24(6), 435-436.
Covvey, J. R., McClendon, C., & Gionfriddo, M. R. (2024). Back to the basics: Guidance for formulating good research questions. Research in Social and Administrative Pharmacy, 20(1), 66-69. https://doi.org/10.1016/j.sapharm.2023.09.009
Cummings, S. R., Browner, W. S., & Hulley, S. B. (2013). Conceiving the research question and developing the study plan. Designing Clinical Research, 4, 14-22.
Data, M. C., Mehta, A., Malley, B., & Walkey, A. (2016). Formulating the research question. Secondary Analysis of Electronic Health Records, 81-92. https://doi.org/10.1007/978-3-319-43742-2_9
De, D., & Singh, S. (2019). Basic understanding of study types and formulating research question for a clinical trial. Indian Dermatology Online Journal, 10(3), 351. https://doi.org/10.4103/idoj.IDOJ_56_19
Díaz García, O., & Pérez Contell, J. (2022). Developing research questions in conversation with the literature: Operationalization & tool support. Empirical Software Engineering, 27, 174. https://doi.org/10.1007/s10664-022-10204-8
Doody, O., & Bailey, M. E. (2016). Setting a research question, aim and objective. Nurse Researcher, 23(4). https://doi.org/10.7748/nr.23.4.19.s5
Dwivedi, S. N. (2023). How to Formulate a Research Question, Hypothesis and Objective for a Clinical Study? Central India Journal of Medical Research, 2(03), 3-7. https://doi.org/10.58999/cijmr.v2i03.133
Fandino, W. (2019). Formulating a good research question: Pearls and pitfalls. Indian Journal of Anaesthesia, 63(8), 611. https://doi.org/10.4103/ija.IJA_198_19
Farrugia, P., Petrisor, B. A., Farrokhyar, F., & Bhandari, M. (2010). Research questions, hypotheses and objectives. Canadian Journal of Surgery, 53(4), 278.
Folgueiras Bertomeu, P., & Sandín Esteban, M. P. (2023). The research question in hermeneutic phenomenology and grounded theory research. The Qualitative Report, 28(5), 1452-1472.  https://doi.org/10.46743/2160-3715/2023.5715
Ganesha, H., & Aithal, P. (2022). PHDRQ Model for Identifying Research Gaps and Formulating A Research Question During Ph. D. Program in India. International Journal of Case Studies in Business, IT and Education, 6(2), 408-421. https://doi.org/10.5281/zenodo.7221760
Goldschmidt, G., & Matthews, B. (2022). Formulating design research questions: A framework. Design Studies, 78, 101062. https://doi.org/10.1016/j.destud.2021.101062
Haynes, R. B. (2006). Forming research questions. Journal of clinical epidemiology, 59(9), 881-886. https://doi.org/10.1016/j.jclinepi.2006.06.006
Heddle, N. M. (2007). The research question. Transfusion, 47(1), 15-17. https://doi.org/10.1111/j.1537-2995.2007.01084.x
Hosseini, M.-S., Jahanshahlou, F., Akbarzadeh, M. A., Zarei, M., & Vaez-Gharamaleki, Y. (2024). Formulating research questions for evidence-based studies. Journal of Medicine, Surgery, and Public Health, 2, 100046. https://doi.org/10.1016/j.glmedi.2023.100046
Hulley Stephen, B., Newman Thomas, B., & Cummings Steven, R. (1994). Designing clinical research, 57-73. https://tilda.tcd.ie/epidemiology-biostatistics-course/course-material/assets/Class2/ Designingclinicalresearch_4th-edition.pdf
Ibrahim, R. (2008). Setting up a research question for determining the research methodology. ALAM CIPTA International Journal on Sustainable Tropical Design Research & Practice, 3(1), 99-102.
Jones, R. (2003). Choosing a research question. Asia Pacific Family Medicine, 2(1), 42-44. https://doi.org/10.1046/j.1444-1683.2003.00050.x
Kamper, S. J. (2018). Asking a question: linking evidence with practice. Journal of Orthopaedic & Sports Physical Therapy, 48(7), 596-597. https://doi.org/10.2519/jospt.2018.0702
Khoo, E. M. (2012). Research questions and research objectives. Malaysian Family Physician, 13(3), 2.
Kishore, J., Vasundhra, S., & Anand, T. (2011). Formulation of a research question. Indian Journal of Medical Specialties, 2(2), 184-188. https://doi.org/10.7713/ijms.2011.0047
Kross, J., & Giust, A. (2019). Elements of research questions in relation to qualitative inquiry. The Qualitative Report, 24(1), 24-30. https://doi.org/10.46743/2160-3715/2019.3426
Kumari, A., Sinha, B., & Ranjan, P. (2017). Research protocol development: basic concepts for clinicians. International Journal of Research in Medical Sciences, 5(5), 1733. http://dx.doi.org/10.18203/2320-6012.ijrms20171462
Lahat, A., Shachar, E., Avidan, B., Shatz, Z., Glicksberg, B. S., & Klang, E. (2023). Evaluating the use of large language model in identifying top research questions in gastroenterology. Scientific Reports, 13(1), 4164. https://doi.org/10.1038/s41598-023-31412-2
Larson, B. (2020). DOURS: A heuristic for discovering research questions. SSRN. http://dx.doi.org/10.2139/ssrn.3688476
Lipowski, E. E. (2008). Developing great research questions. American Journal of Health-System Pharmacy, 65(17), 1667-1670. https://doi.org/10.2146/ajhp070276
Liu, Y., Chen, S., Cheng, H., Yu, M., Ran, X., Mo, A., Tang, Y., & Huang, Y. (2024). CoQuest: Exploring Research Question Co-Creation with an LLM-based Agent. 2024 CHI Conference on Human Factors in Computing Sytems, CHI 2024, https://doi.org/10.1145/3613904.3642698
Liu, Y., Yu, M., Jiang, M., & Huang, Y. (2023). Creative Research Question Generation for Human-Computer Interaction Research. IUI Workshops.
Majid, U. (2017). Research Fundamentals: The research question, outcomes, and background. Undergraduate Research in Natural and Clinical Science and Technology Journal, 1, 1-7. https://doi.org/10.26685/urncst.14
Mattick, K., Johnston, J., & de la Croix, A. (2018). How to… write a good research question. The clinical teacher, 15(2), 104-108. https://doi.org/10.1111/tct.12776
Mayo, N. E., Asano, M., & Barbic, S. P. (2013). When is a research question not a research question? Journal of Rehabilitation Medicine, 45(6), 513-518.
Mbuagbaw, L., & Thabane, L. (2017). The framing of research questions using the PICOT format in randomized controlled trials of venous ulcer disease is sub-optimal: a systematic survey Luciana PF Abbade, PhD; Mei Wang, 2 MD; Kamath Sriganesh, DM; 3, 4 Yanling Jin, 2 MSc. https://doi.org/10.1111/wrr.12592
McCauley, A., & Ruggeri, A. (2020). Formulating Research Questions & Designing Research Projects in International Relations1. The Handbook of Research Methods in Political Science and International Relations, Sage: London.
Mehrabadi, A., Austin, N., Keyes, K. M., & De Vera, M. A. (2024). It’s personal: navigating research questions that stem from our lived experiences. International Journal of Epidemiology, 53(6), Dyae132. https://doi.org/10.1093/ije/dyae132
Nishikawa-Pacher, A. (2022). Research questions with PICO: a universal mnemonic. Publications, 10(3), 21. https://doi.org/10.3390/publications10030021
Onwuegbuzie, A. J., & Leech, N. L. (2006). Linking research questions to mixed methods data analysis procedures. The Qualitative Report, 11(3), 474-498. https://doi.org/10.46743/2160-3715/2006.1663
Parathasarathy, S., Samantaray, A., & Jain, D. (2023). A well-formulated research question: The foundation stone of good research. Indian Journal of Anaesthesia, 67(4), 326-327. https://doi.org/10.4103/ija.ija_226_23
Pecher, D., Chu, Z., & Byrd, V. L. (2020). Developing Research Questions: A method for transforming a question into a problem statement. 2020 IEEE Frontiers in Education Conference (FIE), https://doi.org/10.1109/FIE44824.2020.9274275
Qiu, L., Ikeda, F., & Yamashita, N. (2024). Development of Logic-Based Question Classification Methods to Measure the Ability to Ask Questions Essential for Setting Research Questions. Integrated Science Education Journal, 5(2), 91-100. https://doi.org/10.37251/isej.v5i2.1003
Ratan, S. K., Anand, T., & Ratan, J. (2019). Formulation of research question–Stepwise approach. Journal of Indian Association of Pediatric Surgeons, 24(1), 15. https://doi.org/10.4103/jiaps.JIAPS_76_18
Raymond, J., Chan, V., & Darsaut, T. (2023). Understanding how the research question impacts trial design: Examples from discectomy trials. Neurochirurgie, 69(4), 101460. https://doi.org/10.1016/j.neuchi.2023.101460
Rios, L. P., Ye, C., & Thabane, L. (2010). Association between framing of the research question using the PICOT format and reporting quality of randomized controlled trials. BMC Medical Research Methodology, 10(1), 1-8. https://doi.org/10.1186/1471-2288-10-11
Sánchez-Martín, M., Plana, M. P., Gea, A. I. P., & Navarro-Mateu, F. (2023). And, at first, it was the research question… The PICO, PECO, SPIDER and FINER formats [Y, al principio, fue la pregunta de investigación… Los formatos PICO, PECO, SPIDER y FINER]. Espiral. Cuadernos del Profesorado, 16(32), 126-136. https://doi.org/10.25115/ecp.v16i32.9102
Seehusen, D. A., & Weaver, S. P. (2009). Resident research in family medicine: where are we now. Family Medicine, 41(9), 663-668.
Shahapur, P. R., Vadakedath, S., Bharadwaj, V. G., Kumar, P., Pinnelli, V. B., Godishala, V., & Kandi, V. (2022). Research question, objectives, and endpoints in clinical and oncological research: A comprehensive review. Cureus, 14(9). https://doi.org/10.7759/cureus.29575
Sharma, D., Barla, M. A., & Roushan, R. (2023). Synopsis Writing Guidelines for Health Research Project. Journal of Advanced Research in Medical Science & Technology, 10(1&2), 1-8. https://doi.org/10.24321/2394.6539.202305
Shimada, H. (2017). The Process of Forming Research Questions: Undergraduate Students' Writing Graduation Theses at Waseda University Waseda University].
Shrier, I., & Suzuki, E. (2022). The primary importance of the research question: Implications for understanding natural versus controlled direct effects. In (Vol. 51, pp. 1041-1046): Oxford University Press. https://doi.org/10.1093/ije/dyac090
Skipper, L. K., & Skipper, P. J. (2024). Experimental Design and Scientific Data Analysis. Taylor & Francis. https://doi.org/10.4324/9781003397137
Solarino, A. M., Rose, E. L., & Luise, C. (2024). Going complex or going easy? The impact of research questions on citations. Scientometrics, 129(1), 127-146. https://doi.org/10.1007/s11192-023-04907-y
Stern, M. J., & Powell, R. B. (2024). Identifying relevant research questions: A tentative framework for inquiry in interpretation research. Journal of Interpretation Research, 29(1), 3-9. https://doi.org/10.1177/10925872241249319
Thabane, L., Thomas, T., Ye, C., & Paul, J. (2009). Posing the research question: not so simple. Canadian Journal of Anesthesia, 56(1), 71-79. https://doi.org/10.1007/s12630-008-9007-4
Thelwall, M., & Mas-Bleda, A. (2020). How common are explicit research questions in journal articles? Quantitative Science Studies, 1(2), 730-748. https://doi.org/10.1162/qss_a_00041
Twycross, A. (2004). Research Design: Qualitative, quantitative and mixed methods approaches. Nurse Researcher12(1), 82-84.
Voss, G. B. (2003). Formulating interesting research questions. Journal of the Academy of Marketing Science, 31(3), 356-359. https://doi.org/10.1177/0092070303031003020
Willis, L. D. (2023). Formulating the research question and framing the hypothesis. Respiratory Care, 68(8), 1180-1185. https://doi.org/10.4187/respcare.10975